Chapter I: Front Matter

PUBLISHED ON THE FOUNDATION
ESTABLISHED IN MEMORY OF
ANTHONY N. BRADY

FIG. I. AUTOPSY NO. 99. ACUTE HEMORRHAGIC AND ULCERATIVE
LARYNGOTRACHEITIS.
]

THE
PATHOLOGY OF INFLUENZA

BY
M. C. WINTERNITZ, ISABEL M. WASON AND FRANK P. MCNAMARA

FROM
THE BRADY LABORATORY OF PATHOLOGY AND BACTERIOLOGY, YALE UNIVERSITY
SCHOOL OF MEDICINE AND THE NEW HAVEN HOSPITAL

NEW HAVEN
YALE UNIVERSITY PRESS
LONDON · HUMPHREY MILFORD · OXFORD UNIVERSITY PRESS
MDCCCCXX

COPYRIGHT, 1920, BY
YALE UNIVERSITY PRESS

The present volume is the fourth work published by the Yale University Press on the Anthony N. Brady Memorial Foundation, which was established June 15, 1914, by members of the family of the late Anthony N. Brady to enable the University to declare operative the agreement for an alliance between the New Haven Hospital and the Yale School of Medicine. In addition to the pledge of endowment for this purpose, the donors erected for the University on the grounds of the Hospital a clinical and pathological laboratory, and have since, through additional gifts to supplement the income of the Memorial Foundation, made possible the publication of this and other works by members of the faculty of the School of Medicine at Yale.

Our grateful acknowledgment is due the Staff of
the New Haven Hospital, especially the members
of the Department of Medicine, for their hearty
co-operation and for the use of the clinical
notes. We also wish to thank the members of the
Medical Corps of the United States Army who were
stationed at the Yale Army Laboratory School
while the work was in progress and who aided in
many ways:—Colonel Charles F. Craig, Captain R.
A. Lambert, Lieutenants C. A. McKinlay,
Frederick Parker, Jr., Ellis Kellert, Henry R.
Muller, and J. H. Globus.

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TABLE OF CONTENTS

Page

Introduction 9

I. The Pathology of the Respiratory Tract in Influenza 13

(A) Lesions of the Trachea and Bronchi 13

(a) Gross Picture 13
(b) Histological Picture 14
(c) Summary 16

(B) Lesions of the Lung 16

(1) Acute Diffuse Fulminating Type 18

(a) Gross Picture 18
(b) Summary 19
(c) Histological Picture 20
(d) Summary 22

(2) Localization and Necrotization of the Pneumonic
Process 22

(a) Gross Picture 22
(b) Histological Picture 24
(c) Summary 26

(3) Organization of the Bronchiolar and Pneumonic
Processes 26

(a) Illustrative Protocols 27
(b) Summary 30

II. Influence of the Respiratory Complications of Influenza
upon Tuberculosis of the Lung 32

(a) Illustrative Protocols 32
(b) Summary 33

III. Extrarespiratory Lesions in Influenza 34

(A) Lesions of the Hematopoietic System 34

(a) Lymphadenoid Tissue 34
(b) Spleen 35
(c) Bone Marrow 35

(B) Lesions of the Blood Vessels and Elsewhere in the
Body 36

(a) Vascular System 36
(b) Skeletal System 36
(c) Parenchymatous Organs 36
(d) Alimentary Canal 37
(e) Urinary Bladder 37

(C) Miscellaneous Lesions 38

(a) Parenchymatous Organs 38
(b) Jaundice 39
(c) Central Nervous System 39
(d) The Pregnant Uterus 39
(e) Summary 39