Chapter VI: Book II: The Beginnings of Modern Science (6)

Harvey, the son of a prosperous Kentish yeoman, was born at Folkestone. His education was begun at the grammar-school of Canterbury, and later he became a pensioner of Caius College, Cambridge. Soon after taking his degree of B.A., at the age of nineteen, he decided upon the profession of medicine, and went to Padua as a pupil of Fabricius and Casserius. Returning to England at the age of twenty-four, he soon after (1609) obtained the reversion of the post of physician to St. Bartholomew's Hospital, his application being supported by James I. himself. Even at this time he was a popular physician, counting among his patients such men as Francis Bacon. In 1618 he was appointed physician extraordinary to the king, and, a little later, physician in ordinary. He was in attendance upon Charles I. at the battle of Edgehill, in 1642, where, with the young Prince of Wales and the Duke of York, after seeking shelter under a hedge, he drew a book out of his pocket and, forgetful of the battle, became absorbed in study, until finally the cannon-balls from the enemy's artillery made him seek a more sheltered position.

On the fall of Charles I. he retired from practice, and lived in retirement with his brother. He was then well along in years, but still pursued his scientific researches with the same vigor as before, directing his attention chiefly to the study of embryology. On June 3, 1657, he was attacked by paralysis and died, in his eightieth year. He had lived to see his theory of the circulation accepted, several years before, by all the eminent anatomists of the civilized world.

A keenness in the observation of facts, characteristic of the mind of the man, had led Harvey to doubt the truth of existing doctrines as to the phenomena of the circulation. Galen had taught that "the arteries are filled, like bellows, because they are expanded," but Harvey thought that the action of spurting blood from a severed vessel disproved this. For the spurting was remittant, "now with greater, now with less impetus," and its greater force always corresponded to the expansion (diastole), not the contraction (systole) of the vessel. Furthermore, it was evident that contraction of the heart and the arteries was not simultaneous, as was commonly taught, because in that case there would be no marked propulsion of the blood in any direction; and there was no gainsaying the fact that the blood was forcibly propelled in a definite direction, and that direction away from the heart.

Harvey's investigations led him to doubt also the accepted theory that there was a porosity in the septum of tissue that divides the two ventricles of the heart. It seemed unreasonable to suppose that a thick fluid like the blood could find its way through pores so small that they could not be demonstrated by any means devised by man. In evidence that there could be no such openings he pointed out that, since the two ventricles contract at the same time, this process would impede rather than facilitate such an intra-ventricular passage of blood. But what seemed the most conclusive proof of all was the fact that in the foetus there existed a demonstrable opening between the two ventricles, and yet this is closed in the fully developed heart. Why should Nature, if she intended that blood should pass between the two cavities, choose to close this opening and substitute microscopic openings in place of it? It would surely seem more reasonable to have the small perforations in the thin, easily permeable membrane of the foetus, and the opening in the adult heart, rather than the reverse. From all this Harvey drew his correct conclusions, declaring earnestly, "By Hercules, there ARE no such porosities, and they cannot be demonstrated."

Having convinced himself that no intra-ventricular opening existed, he proceeded to study the action of the heart itself, untrammelled by too much faith in established theories, and, as yet, with no theory of his own. He soon discovered that the commonly accepted theory of the heart striking against the chest-wall during the period of relaxation was entirely wrong, and that its action was exactly the reverse of this, the heart striking the chest-wall during contraction. Having thus disproved the accepted theory concerning the heart's action, he took up the subject of the action of arteries, and soon was able to demonstrate by vivisection that the contraction of the arteries was not simultaneous with contractions of the heart. His experiments demonstrated that these vessels were simply elastic tubes whose pulsations were "nothing else than the impulse of the blood within them." The reason that the arterial pulsation was not simultaneous with the heart-beat he found to be because of the time required to carry the impulse along the tube.

By a series of further careful examinations and experiments, which are too extended to be given here, he was soon able further to demonstrate the action and course of the blood during the contractions of the heart. His explanations were practically the same as those given to-day--first the contraction of the auricle, sending blood into the ventricle; then ventricular contraction, making the pulse, and sending the blood into the arteries. He had thus demonstrated what had not been generally accepted before, that the heart was an organ for the propulsion of blood. To make such a statement to-day seems not unlike the sober announcement that the earth is round or that the sun does not revolve about it. Before Harvey's time, however, it was considered as an organ that was "in some mysterious way the source of vitality and warmth, as an animated crucible for the concoction of blood and the generation of vital spirits."(3)

In watching the rapid and ceaseless contractions of the heart, Harvey was impressed with the fact that, even if a very small amount of blood was sent out at each pulsation, an enormous quantity must pass through the organ in a day, or even in an hour. Estimating the size of the cavities of the heart, and noting that at least a drachm must be sent out with each pulsation, it was evident that the two thousand beats given by a very slow human heart in an hour must send out some forty pounds of blood--more than twice the amount in the entire body. The question was, what became of it all? For it should be remembered that the return of the blood by the veins was unknown, and nothing like a "circulation" more than vaguely conceived even by Harvey himself. Once it could be shown that the veins were constantly returning blood to the heart, the discovery that the blood in some way passes from the arteries to the veins was only a short step. Harvey, by resorting to vivisections of lower animals and reptiles, soon demonstrated beyond question the fact that the veins do carry the return blood. "But this, in particular, can be shown clearer than daylight," says Harvey. "The vena cava enters the heart at an inferior portion, while the artery passes out above. Now if the vena cava be taken up with forceps or the thumb and finger, and the course of the blood intercepted for some distance below the heart, you will at once see it almost emptied between the fingers and the heart, the blood being exhausted by the heart's pulsation, the heart at the same time becoming much paler even in its dilatation, smaller in size, owing to the deficiency of blood, and at length languid in pulsation, as if about to die. On the other hand, when you release the vein the heart immediately regains its color and dimensions. After that, if you leave the vein free and tie and compress the arteries at some distance from the heart, you will see, on the contrary, their included portion grow excessively turgid, the heart becoming so beyond measure, assuming a dark-red color, even to lividity, and at length so overloaded with blood as to seem in danger of suffocation; but when the obstruction is removed it returns to its normal condition, in size, color, and movement."(4)

This conclusive demonstration that the veins return the blood to the heart must have been most impressive to Harvey, who had been taught to believe that the blood current in the veins pursued an opposite course, and must have tended to shake his faith in all existing doctrines of the day.

His next step was the natural one of demonstrating that the blood passes from the arteries to the veins. He demonstrated conclusively that this did occur, but for once his rejection of the ancient writers and one modern one was a mistake. For Galen had taught, and had attempted to demonstrate, that there are sets of minute vessels connecting the arteries and the veins; and Servetus had shown that there must be such vessels, at least in the lungs.

However, the little flaw in the otherwise complete demonstration of Harvey detracts nothing from the main issue at stake. It was for others who followed to show just how these small vessels acted in effecting the transfer of the blood from artery to vein, and the grand general statement that such a transfer does take place was, after all, the all-important one, and the exact method of how it takes place a detail. Harvey's experiments to demonstrate that the blood passes from the arteries to the veins are so simply and concisely stated that they may best be given in his own words.

"I have here to cite certain experiments," he wrote, "from which it seems obvious that the blood enters a limb by the arteries, and returns from it by the veins; that the arteries are the vessels carrying the blood from the heart, and the veins the returning channels of the blood to the heart; that in the limbs and extreme parts of the body the blood passes either by anastomosis from the arteries into the veins, or immediately by the pores of the flesh, or in both ways, as has already been said in speaking of the passage of the blood through the lungs; whence it appears manifest that in the circuit the blood moves from thence hither, and hence thither; from the centre to the extremities, to wit, and from the extreme parts back again to the centre. Finally, upon grounds of circulation, with the same elements as before, it will be obvious that the quantity can neither be accounted for by the ingesta, nor yet be held necessary to nutrition.

"Now let any one make an experiment on the arm of a man, either using such a fillet as is employed in blood-letting or grasping the limb tightly with his hand, the best subject for it being one who is lean, and who has large veins, and the best time after exercise, when the body is warm, the pulse is full, and the blood carried in large quantities to the extremities, for all then is more conspicuous; under such circumstances let a ligature be thrown about the extremity and drawn as tightly as can be borne: it will first be perceived that beyond the ligature neither in the wrist nor anywhere else do the arteries pulsate, that at the same time immediately above the ligature the artery begins to rise higher at each diastole, to throb more violently, and to swell in its vicinity with a kind of tide, as if it strove to break through and overcome the obstacle to its current; the artery here, in short, appears as if it were permanently full. The hand under such circumstances retains its natural color and appearances; in the course of time it begins to fall somewhat in temperature, indeed, but nothing is DRAWN into it.

"After the bandage has been kept on some short time in this way, let it be slackened a little, brought to the state or term of middling tightness which is used in bleeding, and it will be seen that the whole hand and arm will instantly become deeply suffused and distended, injected, gorged with blood, DRAWN, as it is said, by this middling ligature, without pain, or heat, or any horror of a vacuum, or any other cause yet indicated.

"As we have noted, in connection with the tight ligature, that the artery above the bandage was distended and pulsated, not below it, so, in the case of the moderately tight bandage, on the contrary, do we find that the veins below, never above, the fillet swell and become dilated, while the arteries shrink; and such is the degree of distention of the veins here that it is only very strong pressure that will force the blood beyond the fillet and cause any of the veins in the upper part of the arm to rise.

"From these facts it is easy for any careful observer to learn that the blood enters an extremity by the arteries; for when they are effectively compressed nothing is DRAWN to the member; the hand preserves its color; nothing flows into it, neither is it distended; but when the pressure is diminished, as it is with the bleeding fillet, it is manifest that the blood is instantly thrown in with force, for then the hand begins to swell; which is as much as to say that when the arteries pulsate the blood is flowing through them, as it is when the moderately tight ligature is applied; but when they do not pulsate, or when a tight ligature is used, they cease from transmitting anything; they are only distended above the part where the ligature is applied. The veins again being compressed, nothing can flow through them; the certain indication of which is that below the ligature they are much more tumid than above it, and than they usually appear when there is no bandage upon the arm.

"It therefore plainly appears that the ligature prevents the return of the blood through the veins to the parts above it, and maintains those beneath it in a state of permanent distention. But the arteries, in spite of the pressure, and under the force and impulse of the heart, send on the blood from the internal parts of the body to the parts beyond the bandage."(5)

This use of ligatures is very significant, because, as shown, a very tight ligature stops circulation in both arteries and veins, while a loose one, while checking the circulation in the veins, which lie nearer the surface and are not so directly influenced by the force of the heart, does not stop the passage of blood in the arteries, which are usually deeply imbedded in the tissues, and not so easily influenced by pressure from without.

The last step of Harvey's demonstration was to prove that the blood does flow along the veins to the heart, aided by the valves that had been the cause of so much discussion and dispute between the great sixteenth-century anatomists. Harvey not only demonstrated the presence of these valves, but showed conclusively, by simple experiments, what their function was, thus completing his demonstration of the phenomena of the circulation.

The final ocular demonstration of the passage of the blood from the arteries to the veins was not to be made until four years after Harvey's death. This process, which can be observed easily in the web of a frog's foot by the aid of a low-power lens, was first demonstrated by Marcello Malpighi (1628-1694) in 1661. By the aid of a lens he first saw the small "capillary" vessels connecting the veins and arteries in a piece of dried lung. Taking his cue from this, he examined the lung of a turtle, and was able to see in it the passage of the corpuscles through these minute vessels, making their way along these previously unknown channels from the arteries into the veins on their journey back to the heart. Thus the work of Harvey, all but complete, was made absolutely entire by the great Italian. And all this in a single generation.

LEEUWENHOEK DISCOVERS BACTERIA

The seventeenth century was not to close, however, without another discovery in science, which, when applied to the causation of disease almost two centuries later, revolutionized therapeutics more completely than any one discovery. This was the discovery of microbes, by Antonius von Leeuwenhoek (1632-1723), in 1683. Von Leeuwenhoek discovered that "in the white matter between his teeth" there were millions of microscopic "animals"--more, in fact, than "there were human beings in the united Netherlands," and all "moving in the most delightful manner." There can be no question that he saw them, for we can recognize in his descriptions of these various forms of little "animals" the four principal forms of microbes--the long and short rods of bacilli and bacteria, the spheres of micrococci, and the corkscrew spirillum.

The presence of these microbes in his mouth greatly annoyed Antonius, and he tried various methods of getting rid of them, such as using vinegar and hot coffee. In doing this he little suspected that he was anticipating modern antiseptic surgery by a century and three-quarters, and to be attempting what antiseptic surgery is now able to accomplish. For the fundamental principle of antisepsis is the use of medicines for ridding wounds of similar microscopic organisms. Von Leenwenhoek was only temporarily successful in his attempts, however, and took occasion to communicate his discovery to the Royal Society of England, hoping that they would be "interested in this novelty." Probably they were, but not sufficiently so for any member to pursue any protracted investigations or reach any satisfactory conclusions, and the whole matter was practically forgotten until the middle of the nineteenth century.

VIII. MEDICINE IN THE SIXTEENTH AND SEVENTEENTH CENTURIES

Of the half-dozen surgeons who were prominent in the sixteenth century, Ambroise Pare (1517-1590), called the father of French surgery, is perhaps the most widely known. He rose from the position of a common barber to that of surgeon to three French monarchs, Henry II., Francis II., and Charles IX. Some of his mottoes are still first principles of the medical man. Among others are: "He who becomes a surgeon for the sake of money, and not for the sake of knowledge, will accomplish nothing"; and "A tried remedy is better than a newly invented." On his statue is his modest estimate of his work in caring for the wounded, "Je le pansay, Dieu le guarit"--I dressed him, God cured him.

It was in this dressing of wounds on the battlefield that he accidentally discovered how useless and harmful was the terribly painful treatment of applying boiling oil to gunshot wounds as advocated by John of Vigo. It happened that after a certain battle, where there was an unusually large number of casualties, Pare found, to his horror, that no more boiling oil was available for the surgeons, and that he should be obliged to dress the wounded by other simpler methods. To his amazement the results proved entirely satisfactory, and from that day he discarded the hot-oil treatment.

As Pare did not understand Latin he wrote his treatises in French, thus inaugurating a custom in France that was begun by Paracelsus in Germany half a century before. He reintroduced the use of the ligature in controlling hemorrhage, introduced the "figure of eight" suture in the operation for hare-lip, improved many of the medico-legal doctrines, and advanced the practice of surgery generally. He is credited with having successfully performed the operation for strangulated hernia, but he probably borrowed it from Peter Franco (1505-1570), who published an account of this operation in 1556. As this operation is considered by some the most important operation in surgery, its discoverer is entitled to more than passing notice, although he was despised and ignored by the surgeons of his time.

Franco was an illiterate travelling lithotomist--a class of itinerant physicians who were very generally frowned down by the regular practitioners of medicine. But Franco possessed such skill as an operator, and appears to have been so earnest in the pursuit of what he considered a legitimate calling, that he finally overcame the popular prejudice and became one of the salaried surgeons of the republic of Bern. He was the first surgeon to perform the suprapubic lithotomy operation--the removal of stone through the abdomen instead of through the perineum. His works, while written in an illiterate style, give the clearest descriptions of any of the early modern writers.

As the fame of Franco rests upon his operation for prolonging human life, so the fame of his Italian contemporary, Gaspar Tagliacozzi (1545-1599), rests upon his operation for increasing human comfort and happiness by restoring amputated noses. At the time in which he lived amputation of the nose was very common, partly from disease, but also because a certain pope had fixed the amputation of that member as the penalty for larceny. Tagliacozzi probably borrowed his operation from the East; but he was the first Western surgeon to perform it and describe it. So great was the fame of his operations that patients flocked to him from all over Europe, and each "went away with as many noses as he liked." Naturally, the man who directed his efforts to restoring structures that bad been removed by order of the Church was regarded in the light of a heretic by many theologians; and though he succeeded in cheating the stake or dungeon, and died a natural death, his body was finally cast out of the church in which it had been buried.

In the sixteenth century Germany produced a surgeon, Fabricius Hildanes (1560-1639), whose work compares favorably with that of Pare, and whose name would undoubtedly have been much better known had not the circumstances of the time in which he lived tended to obscure his merits. The blind followers of Paracelsus could see nothing outside the pale of their master's teachings, and the disastrous Thirty Years' War tended to obscure and retard all scientific advances in Germany. Unlike many of his fellow-surgeons, Hildanes was well versed in Latin and Greek; and, contrary to the teachings of Paracelsus, he laid particular stress upon the necessity of the surgeon having a thorough knowledge of anatomy. He had a helpmate in his wife, who was also something of a surgeon, and she is credited with having first made use of the magnet in removing particles of metal from the eye. Hildanes tells of a certain man who had been injured by a small piece of steel in the cornea, which resisted all his efforts to remove it. After observing Hildanes' fruitless efforts for a time, it suddenly occurred to his wife to attempt to make the extraction with a piece of loadstone. While the physician held open the two lids, his wife attempted to withdraw the steel with the magnet held close to the cornea, and after several efforts she was successful--which Hildanes enumerates as one of the advantages of being a married man.

Hildanes was particularly happy in his inventions of surgical instruments, many of which were designed for locating and removing the various missiles recently introduced in warfare.

The seventeenth century, which was such a flourishing one for anatomy and physiology, was not as productive of great surgeons or advances in surgery as the sixteenth had been or the eighteenth was to be. There was a gradual improvement all along the line, however, and much of the work begun by such surgeons as Pare and Hildanes was perfected or improved. Perhaps the most progressive surgeon of the century was an Englishman, Richard Wiseman (1625-1686), who, like Harvey, enjoyed royal favor, being in the service of all the Stuart kings. He was the first surgeon to advocate primary amputation, in gunshot wounds, of the limbs, and also to introduce the treatment of aneurisms by compression; but he is generally rated as a conservative operator, who favored medication rather than radical operations, where possible.

In Italy, Marcus Aurelius Severinus (1580-1656) and Peter Marchettis (1589-1675) were the leading surgeons of their nation. Like many of his predecessors in Europe, Severinus ran amuck with the Holy Inquisition and fled from Naples. But the waning of the powerful arm of the Church is shown by the fact that he was brought back by the unanimous voice of the grateful citizens, and lived in safety despite the frowns of the theologians.

The sixteenth century cannot be said to have added much of importance in the field of practical medicine, and, as in the preceding and succeeding centuries, was at best only struggling along in the wake of anatomy, physiology, and surgery. In the seventeenth century, however, at least one discovery in therapeutics was made that has been an inestimable boon to humanity ever since. This was the introduction of cinchona bark (from which quinine is obtained) in 1640. But this century was productive of many medical SYSTEMS, and could boast of many great names among the medical profession, and, on the whole, made considerably more progress than the preceding century.

Of the founders of medical systems, one of the most widely known is Jan Baptista van Helmont (1578-1644), an eccentric genius who constructed a system of medicine of his own and for a time exerted considerable influence. But in the end his system was destined to pass out of existence, not very long after the death of its author. Van Helmont was not only a physician, but was master of all the other branches of learning of the time, taking up the study of medicine and chemistry as an after-thought, but devoting himself to them with the greatest enthusiasm once he had begun his investigations. His attitude towards existing doctrines was as revolutionary as that of Paracelsus, and he rejected the teachings of Galen and all the ancient writers, although retaining some of the views of Paracelsus. He modified the archaeus of Paracelsus, and added many complications to it. He believed the whole body to be controlled by an archaeus influus, the soul by the archaei insiti, and these in turn controlled by the central archeus. His system is too elaborate and complicated for full explanation, but its chief service to medicine was in introducing new chemical methods in the preparation of drugs. In this way he was indirectly connected with the establishment of the Iatrochemical school. It was he who first used the word "gas"--a word coined by him, along with many others that soon fell into disuse.

The principles of the Iatrochemical school were the use of chemical medicines, and a theory of pathology different from the prevailing "humoral" pathology. The founder of this school was Sylvius (Franz de le Boe, 1614-1672), professor of medicine at Leyden. He attempted to establish a permanent system of medicine based on the newly discovered theory of the circulation and the new chemistry, but his name is remembered by medical men because of the fissure in the brain (fissure of Sylvius) that bears it. He laid great stress on the cause of fevers and other diseases as originating in the disturbances of the process of fermentation in the stomach. The doctrines of Sylvius spread widely over the continent, but were not generally accepted in England until modified by Thomas Willis (1622-1675), whose name, like that of Sylvius, is perpetuated by a structure in the brain named after him, the circle of Willis. Willis's descriptions of certain nervous diseases, and an account of diabetes, are the first recorded, and added materially to scientific medicine. These schools of medicine lasted until the end of the seventeenth century, when they were finally overthrown by Sydenham.

The Iatrophysical school (also called iatromathematical, iatromechanical, or physiatric) was founded on theories of physiology, probably by Borelli, of Naples (1608-1679), although Sanctorius; Sanctorius, a professor at Padua, was a precursor, if not directly interested in establishing it. Sanctorius discovered the fact that an "insensible perspiration" is being given off by the body continually, and was amazed to find that loss of weight in this way far exceeded the loss of weight by all other excretions of the body combined. He made this discovery by means of a peculiar weighing-machine to which a chair was attached, and in which he spent most of his time. Very naturally he overestimated the importance of this discovery, but it was, nevertheless, of great value in pointing out the hygienic importance of the care of the skin. He also introduced a thermometer which he advocated as valuable in cases of fever, but the instrument was probably not his own invention, but borrowed from his friend Galileo.

Harvey's discovery of the circulation of the blood laid the foundation of the Iatrophysical school by showing that this vital process was comparable to a hydraulic system. In his On the Motive of Animals, Borelli first attempted to account for the phenomena of life and diseases on these principles. The iatromechanics held that the great cause of disease is due to different states of elasticity of the solids of the body interfering with the movements of the fluids, which are themselves subject to changes in density, one or both of these conditions continuing to cause stagnation or congestion. The school thus founded by Borelli was the outcome of the unbounded enthusiasm, with its accompanying exaggeration of certain phenomena with the corresponding belittling of others that naturally follows such a revolutionary discovery as that of Harvey. Having such a founder as the brilliant Italian Borelli, it was given a sufficient impetus by his writings to carry it some distance before it finally collapsed. Some of the exaggerated mathematical calculations of Borelli himself are worth noting. Each heart-beat, as he calculated it, overcomes a resistance equal to one hundred and eighty thousand pounds;--the modern physiologist estimates its force at from five to nine ounces!

THOMAS SYDENHAM

But while the Continent was struggling with these illusive "systems," and dabbling in mystic theories that were to scarcely outlive the men who conceived them, there appeared in England--the "land of common-sense," as a German scientist has called it--"a cool, clear, and unprejudiced spirit," who in the golden age of systems declined "to be like the man who builds the chambers of the upper story of his house before he had laid securely the foundation walls."(1) This man was Thomas Sydenham (1624-1689), who, while the great Harvey was serving the king as surgeon, was fighting as a captain in the parliamentary army. Sydenham took for his guide the teachings of Hippocrates, modified to suit the advances that had been made in scientific knowledge since the days of the great Greek, and established, as a standard, observation and experience. He cared little for theory unless confirmed by practice, but took the Hippocratic view that nature cured diseases, assisted by the physician. He gave due credit, however, to the importance of the part played by the assistant. As he saw it, medicine could be advanced in three ways: (1) "By accurate descriptions or natural histories of diseases; (2) by establishing a fixed principle or method of treatment, founded upon experience; (3) by searching for specific remedies, which he believes must exist in considerable numbers, though he admits that the only one yet discovered is Peruvian bark."(2) As it happened, another equally specific remedy, mercury, when used in certain diseases, was already known to him, but he evidently did not recognize it as such.

The influence on future medicine of Sydenham's teachings was most pronounced, due mostly to his teaching of careful observation. To most physicians, however, he is now remembered chiefly for his introduction of the use of laudanum, still considered one of the most valuable remedies of modern pharmacopoeias. The German gives the honor of introducing this preparation to Paracelsus, but the English-speaking world will always believe that the credit should be given to Sydenham.

IX. PHILOSOPHER-SCIENTISTS AND NEW INSTITUTIONS OF LEARNING

We saw that in the old Greek days there was no sharp line of demarcation between the field of the philosopher and that of the scientist. In the Hellenistic epoch, however, knowledge became more specialized, and our recent chapters have shown us scientific investigators whose efforts were far enough removed from the intangibilities of the philosopher. It must not be overlooked, however, that even in the present epoch there were men whose intellectual efforts were primarily directed towards the subtleties of philosophy, yet who had also a penchant for strictly scientific imaginings, if not indeed for practical scientific experiments. At least three of these men were of sufficient importance in the history of the development of science to demand more than passing notice. These three are the Englishman Francis Bacon (1561-1626), the Frenchman Rene Descartes (1596-1650); and the German Gottfried Leibnitz (1646-1716). Bacon, as the earliest path-breaker, showed the way, theoretically at least, in which the sciences should be studied; Descartes, pursuing the methods pointed out by Bacon, carried the same line of abstract reason into practice as well; while Leibnitz, coming some years later, and having the advantage of the wisdom of his two great predecessors, was naturally influenced by both in his views of abstract scientific principles.

Bacon's career as a statesman and his faults and misfortunes as a man do not concern us here. Our interest in him begins with his entrance into Trinity College, Cambridge, where he took up the study of all the sciences taught there at that time. During the three years he became more and more convinced that science was not being studied in a profitable manner, until at last, at the end of his college course, he made ready to renounce the old Aristotelian methods of study and advance his theory of inductive study. For although he was a great admirer of Aristotle's work, he became convinced that his methods of approaching study were entirely wrong.

"The opinion of Aristotle," he says, in his De Argumentum Scientiarum, "seemeth to me a negligent opinion, that of those things which exist by nature nothing can be changed by custom; using for example, that if a stone be thrown ten thousand times up it will not learn to ascend; and that by often seeing or hearing we do not learn to see or hear better. For though this principle be true in things wherein nature is peremptory (the reason whereof we cannot now stand to discuss), yet it is otherwise in things wherein nature admitteth a latitude. For he might see that a straight glove will come more easily on with use; and that a wand will by use bend otherwise than it grew; and that by use of the voice we speak louder and stronger; and that by use of enduring heat or cold we endure it the better, and the like; which latter sort have a nearer resemblance unto that subject of manners he handleth than those instances which he allegeth."(1)

These were his opinions, formed while a young man in college, repeated at intervals through his maturer years, and reiterated and emphasized in his old age. Masses of facts were to be obtained by observing nature at first hand, and from such accumulations of facts deductions were to be made. In short, reasoning was to be from the specific to the general, and not vice versa.

It was by his teachings alone that Bacon thus contributed to the foundation of modern science; and, while he was constantly thinking and writing on scientific subjects, he contributed little in the way of actual discoveries. "I only sound the clarion," he said, "but I enter not the battle."

The case of Descartes, however, is different. He both sounded the clarion and entered into the fight. He himself freely acknowledges his debt to Bacon for his teachings of inductive methods of study, but modern criticism places his work on the same plane as that of the great Englishman. "If you lay hold of any characteristic product of modern ways of thinking," says Huxley, "either in the region of philosophy or in that of science, you find the spirit of that thought, if not its form, has been present in the mind of the great Frenchman."(2)

Descartes, the son of a noble family of France, was educated by Jesuit teachers. Like Bacon, he very early conceived the idea that the methods of teaching and studying science were wrong, but be pondered the matter well into middle life before putting into writing his ideas of philosophy and science. Then, in his Discourse Touching the Method of Using One's Reason Rightly and of Seeking Scientific Truth, he pointed out the way of seeking after truth. His central idea in this was to emphasize the importance of DOUBT, and avoidance of accepting as truth anything that does not admit of absolute and unqualified proof. In reaching these conclusions he had before him the striking examples of scientific deductions by Galileo, and more recently the discovery of the circulation of the blood by Harvey. This last came as a revelation to scientists, reducing this seemingly occult process, as it did, to the field of mechanical phenomena. The same mechanical laws that governed the heavenly bodies, as shown by Galileo, governed the action of the human heart, and, for aught any one knew, every part of the body, and even the mind itself.

Having once conceived this idea, Descartes began a series of dissections and experiments upon the lower animals, to find, if possible, further proof of this general law. To him the human body was simply a machine, a complicated mechanism, whose functions were controlled just as any other piece of machinery. He compared the human body to complicated machinery run by water-falls and complicated pipes. "The nerves of the machine which I am describing," he says, "may very well be compared to the pipes of these waterworks; its muscles and its tendons to the other various engines and springs which seem to move them; its animal spirits to the water which impels them, of which the heart is the fountain; while the cavities of the brain are the central office. Moreover, respiration and other such actions as are natural and usual in the body, and which depend on the course of the spirits, are like the movements of a clock, or a mill, which may be kept up by the ordinary flow of water."(3)

In such passages as these Descartes anticipates the ideas of physiology of the present time. He believed that the functions are performed by the various organs of the bodies of animals and men as a mechanism, to which in man was added the soul. This soul he located in the pineal gland, a degenerate and presumably functionless little organ in the brain. For years Descartes's idea of the function of this gland was held by many physiologists, and it was only the introduction of modern high-power microscopy that reduced this also to a mere mechanism, and showed that it is apparently the remains of a Cyclopean eye once common to man's remote ancestors.

Descartes was the originator of a theory of the movements of the universe by a mechanical process--the Cartesian theory of vortices--which for several decades after its promulgation reigned supreme in science. It is the ingenuity of this theory, not the truth of its assertions, that still excites admiration, for it has long since been supplanted. It was certainly the best hitherto advanced--the best "that the observations of the age admitted," according to D'Alembert.

According to this theory the infinite universe is full of matter, there being no such thing as a vacuum. Matter, as Descartes believed, is uniform in character throughout the entire universe, and since motion cannot take place in any part of a space completely filled, without simultaneous movement in all other parts, there are constant more or less circular movements, vortices, or whirlpools of particles, varying, of course, in size and velocity. As a result of this circular movement the particles of matter tend to become globular from contact with one another. Two species of matter are thus formed, one larger and globular, which continue their circular motion with a constant tendency to fly from the centre of the axis of rotation, the other composed of the clippings resulting from the grinding process. These smaller "filings" from the main bodies, becoming smaller and smaller, gradually lose their velocity and accumulate in the centre of the vortex. This collection of the smaller matter in the centre of the vortex constitutes the sun or star, while the spherical particles propelled in straight lines from the centre towards the circumference of the vortex produce the phenomenon of light radiating from the central star. Thus this matter becomes the atmosphere revolving around the accumulation at the centre. But the small particles being constantly worn away from the revolving spherical particles in the vortex, become entangled in their passage, and when they reach the edge of the inner strata of solar dust they settle upon it and form what we call sun-spots. These are constantly dissolved and reformed, until sometimes they form a crust round the central nucleus.

As the expansive force of the star diminishes in the course of time, it is encroached upon by neighboring vortices. If the part of the encroaching star be of a less velocity than the star which it has swept up, it will presently lose its hold, and the smaller star pass out of range, becoming a comet. But if the velocity of the vortex into which the incrusted star settles be equivalent to that of the surrounded vortex, it will hold it as a captive, still revolving and "wrapt in its own firmament." Thus the several planets of our solar system have been captured and held by the sun-vortex, as have the moon and other satellites.

But although these new theories at first created great enthusiasm among all classes of philosophers and scientists, they soon came under the ban of the Church. While no actual harm came to Descartes himself, his writings were condemned by the Catholic and Protestant churches alike. The spirit of philosophical inquiry he had engendered, however, lived on, and is largely responsible for modern philosophy.

In many ways the life and works of Leibnitz remind us of Bacon rather than Descartes. His life was spent in filling high political positions, and his philosophical and scientific writings were by-paths of his fertile mind. He was a theoretical rather than a practical scientist, his contributions to science being in the nature of philosophical reasonings rather than practical demonstrations. Had he been able to withdraw from public life and devote himself to science alone, as Descartes did, he would undoubtedly have proved himself equally great as a practical worker. But during the time of his greatest activity in philosophical fields, between the years 1690 and 1716, he was all the time performing extraordinary active duties in entirely foreign fields. His work may be regarded, perhaps, as doing for Germany in particular what Bacon's did for England and the rest of the world in general.

Only a comparatively small part of his philosophical writings concern us here. According to his theory of the ultimate elements of the universe, the entire universe is composed of individual centres, or monads. To these monads he ascribed numberless qualities by which every phase of nature may be accounted. They were supposed by him to be percipient, self-acting beings, not under arbitrary control of the deity, and yet God himself was the original monad from which all the rest are generated. With this conception as a basis, Leibnitz deduced his doctrine of pre-established harmony, whereby the numerous independent substances composing the world are made to form one universe. He believed that by virtue of an inward energy monads develop themselves spontaneously, each being independent of every other. In short, each monad is a kind of deity in itself--a microcosm representing all the great features of the macrocosm.

It would be impossible clearly to estimate the precise value of the stimulative influence of these philosophers upon the scientific thought of their time. There was one way, however, in which their influence was made very tangible--namely, in the incentive they gave to the foundation of scientific societies.

SCIENTIFIC SOCIETIES

At the present time, when the elements of time and distance are practically eliminated in the propagation of news, and when cheap printing has minimized the difficulties of publishing scientific discoveries, it is difficult to understand the isolated position of the scientific investigation of the ages that preceded steam and electricity. Shut off from the world and completely out of touch with fellow-laborers perhaps only a few miles away, the investigators were naturally seriously handicapped; and inventions and discoveries were not made with the same rapidity that they would undoubtedly have been had the same men been receiving daily, weekly, or monthly communications from fellow-laborers all over the world, as they do to-day. Neither did they have the advantage of public or semi-public laboratories, where they were brought into contact with other men, from whom to gather fresh trains of thought and receive the stimulus of their successes or failures. In the natural course of events, however, neighbors who were interested in somewhat similar pursuits, not of the character of the rivalry of trade or commerce, would meet more or less frequently and discuss their progress. The mutual advantages of such intercourse would be at once appreciated; and it would be but a short step from the casual meeting of two neighborly scientists to the establishment of "societies," meeting at fixed times, and composed of members living within reasonable travelling distance. There would, perhaps, be the weekly or monthly meetings of men in a limited area; and as the natural outgrowth of these little local societies, with frequent meetings, would come the formation of larger societies, meeting less often, where members travelled a considerable distance to attend. And, finally, with increased facilities for communication and travel, the great international societies of to-day would be produced--the natural outcome of the neighborly meetings of the primitive mediaeval investigators.

In Italy, at about the time of Galileo, several small societies were formed. One of the most important of these was the Lyncean Society, founded about the year 1611, Galileo himself being a member. This society was succeeded by the Accademia del Cimento, at Florence, in 1657, which for a time flourished, with such a famous scientist as Torricelli as one of its members.

In England an impetus seems to have been given by Sir Francis Bacon's writings in criticism and censure of the system of teaching in colleges. It is supposed that his suggestions as to what should be the aims of a scientific society led eventually to the establishment of the Royal Society. He pointed out how little had really been accomplished by the existing institutions of learning in advancing science, and asserted that little good could ever come from them while their methods of teaching remained unchanged. He contended that the system which made the lectures and exercises of such a nature that no deviation from the established routine could be thought of was pernicious. But he showed that if any teacher had the temerity to turn from the traditional paths, the daring pioneer was likely to find insurmountable obstacles placed in the way of his advancement. The studies were "imprisoned" within the limits of a certain set of authors, and originality in thought or teaching was to be neither contemplated nor tolerated.

The words of Bacon, given in strong and unsparing terms of censure and condemnation, but nevertheless with perfect justification, soon bore fruit. As early as the year 1645 a small company of scientists had been in the habit of meeting at some place in London to discuss philosophical and scientific subjects for mental advancement. In 1648, owing to the political disturbances of the time, some of the members of these meetings removed to Oxford, among them Boyle, Wallis, and Wren, where the meetings were continued, as were also the meetings of those left in London. In 1662, however, when the political situation bad become more settled, these two bodies of men were united under a charter from Charles II., and Bacon's ideas were practically expressed in that learned body, the Royal Society of London. And it matters little that in some respects Bacon's views were not followed in the practical workings of the society, or that the division of labor in the early stages was somewhat different than at present. The aim of the society has always been one for the advancement of learning; and if Bacon himself could look over its records, he would surely have little fault to find with the aid it has given in carrying out his ideas for the promulgation of useful knowledge.

Ten years after the charter was granted to the Royal Society of London, Lord Bacon's words took practical effect in Germany, with the result that the Academia Naturae Curiosorum was founded, under the leadership of Professor J. C. Sturm. The early labors of this society were devoted to a repetition of the most notable experiments of the time, and the work of the embryo society was published in two volumes, in 1672 and 1685 respectively, which were practically text-books of the physics of the period. It was not until 1700 that Frederick I. founded the Royal Academy of Sciences at Berlin, after the elaborate plan of Leibnitz, who was himself the first president.

Perhaps the nearest realization of Bacon's ideal, however, is in the Royal Academy of Sciences at Paris, which was founded in 1666 under the administration of Colbert, during the reign of Louis XIV. This institution not only recognized independent members, but had besides twenty pensionnaires who received salaries from the government. In this way a select body of scientists were enabled to pursue their investigations without being obliged to "give thought to the morrow" for their sustenance. In return they were to furnish the meetings with scientific memoirs, and once a year give an account of the work they were engaged upon. Thus a certain number of the brightest minds were encouraged to devote their entire time to scientific research, "delivered alike from the temptations of wealth or the embarrassments of poverty." That such a plan works well is amply attested by the results emanating from the French academy. Pensionnaires in various branches of science, however, either paid by the state or by learned societies, are no longer confined to France.

Among the other early scientific societies was the Imperial Academy of Sciences at St. Petersburg, projected by Peter the Great, and established by his widow, Catharine I., in 1725; and also the Royal Swedish Academy, incorporated in 1781, and counting among its early members such men as the celebrated Linnaeus. But after the first impulse had resulted in a few learned societies, their manifest advantage was so evident that additional numbers increased rapidly, until at present almost every branch of every science is represented by more or less important bodies; and these are, individually and collectively, adding to knowledge and stimulating interest in the many fields of science, thus vindicating Lord Bacon's asseverations that knowledge could be satisfactorily promulgated in this manner.

X. THE SUCCESSORS OF GALILEO IN PHYSICAL SCIENCE

We have now to witness the diversified efforts of a company of men who, working for the most part independently, greatly added to the data of the physical sciences--such men as Boyle, Huygens, Von Gericke, and Hooke. It will be found that the studies of these men covered the whole field of physical sciences as then understood--the field of so-called natural philosophy. We shall best treat these successors of Galileo and precursors of Newton somewhat biographically, pointing out the correspondences and differences between their various accomplishments as we proceed. It will be noted in due course that the work of some of them was anticipatory of great achievements of a later century.

ROBERT BOYLE (1627-1691)

Some of Robert Boyle's views as to the possible structure of atmospheric air will be considered a little farther on in this chapter, but for the moment we will take up the consideration of some of his experiments upon that as well as other gases. Boyle was always much interested in alchemy, and carried on extensive experiments in attempting to accomplish the transmutation of metals; but he did not confine himself to these experiments, devoting himself to researches in all the fields of natural philosophy. He was associated at Oxford with a company of scientists, including Wallis and Wren, who held meetings and made experiments together, these gatherings being the beginning, as mentioned a moment ago, of what finally became the Royal Society. It was during this residence at Oxford that many of his valuable researches upon air were made, and during this time be invented his air-pump, now exhibited in the Royal Society rooms at Burlington House.(1)

His experiments to prove the atmospheric pressure are most interesting and conclusive. "Having three small, round glass bubbles, blown at the flame of a lamp, about the size of hazel-nuts," he says, "each of them with a short, slender stem, by means whereof they were so exactly poised in water that a very small change of weight would make them either emerge or sink; at a time when the atmosphere was of convenient weight, I put them into a wide-mouthed glass of common water, and leaving them in a quiet place, where they were frequently in my eye, I observed that sometimes they would be at the top of the water, and remain there for several days, or perhaps weeks, together, and sometimes fall to the bottom, and after having continued there for some time rise again. And sometimes they would rise or fall as the air was hot or cold."(2)