Chapter III: Part 3

_Treatment._--In the first place the ox should be examined by passing the oiled hand and arm into the rectum; the hand should be passed along the margin of the pelvis, beginning at the sacrum and continuing downward toward the inguinal ring, when a soft, painful swelling will be felt, which may vary from the size of an apple to that of the two fists. This swelling will be felt to be tightly compressed by the spermatic cord. It very rarely happens that there is any similar swelling on the left side, though in such cases it is best to make a thorough examination. The bowel has sometimes been released from its position by driving the ox down a hill; by causing him to jump from a height of 2 feet to the ground; the expedient of trotting him also has been resorted to with the hope that the jolting movement might bring about a release of the bowel. If the simple expedients mentioned have been tried and failed, then the hand being passed into the rectum should be pressed gently on the swelling in an upward and forward direction, so as to endeavor to push the imprisoned portion of the bowel back into the abdomen. While this is being done the ox's hind feet should stand on higher ground than the front, so as to favor the slipping out of the bowel by its own weight, and at the same time an assistant should squeeze the animal's loins, so as to cause it to bend downward and so relax the band formed by the spermatic cord. If the imprisoned portion of gut is freed, which may be ascertained by the disappearance of the swelling, the usual sounds produced by the bowels moving in the abdomen will be heard, and in a few hours the feces and urine will be passed as usual. If the means mentioned fail to release the imprisoned portion of the gut, then an incision about 4 inches long must be made in the right flank in a downward direction, the hand introduced into the abdomen, the situation and condition of swelling exactly ascertained, and then a probe-pointed knife inserted between the imprisoned bowel and band compressing it, and turned outward against the band, the latter being then cautiously divided and the imprisoned gut allowed to escape, or, if necessary, the bowel should be drawn gently from its position into the abdomen. The wound in the flank must be brought together in the same way as in the case of the wound made in operating for impaction of the rumen.

WOUNDS OF THE ABDOMEN.

A wound of the abdomen may merely penetrate the skin; but as such cases are not attended with much danger, nor their treatment with much difficulty, we will consider here merely those wounds which penetrate the entire thickness of the abdominal walls and expose to a greater or less extent the organs contained in that cavity.

_Causes._--Such accidents may be occasioned by falling on fragments of broken glass or other sharp objects. A blow from the horn of another animal may penetrate the abdomen. Exposure and protrusion of some of the abdominal organs may also be occasioned by the incautious use of caustics in the treatment of umbilical or ventral hernia. The parts which generally escape through an abdominal wound are the small intestine and floating colon.

_Symptoms._--When the abdominal wound is small, the bowel exposed presents the appearance of a small round tumor, but in a few moments a loop of intestine may emerge from the opening. The animal then shows symptoms of severe pain by pawing with his feet, which has the effect of accelerating the passage of new loops of intestine through the wound, so that the mass which they form may even touch the ground. The pain becomes so great that the ox now not only paws but lies down and rolls, thus tearing and crushing his bowels. In such cases it is best to slaughter the animal at once; but in the case of a valuable animal in which tearing and crushing of the bowels has not taken place the bowels should be washed with freshly boiled water reduced to the temperature of the body and returned and the wounds in the muscle and skin brought together in a manner somewhat similar to that described in speaking of ventral hernia.

DISEASES OF THE LIVER AND SPLEEN.

JAUNDICE (THE YELLOWS, OR CONGESTION OF THE LIVER).

When jaundice exists, there is a yellow appearance of the white of the eyes and of the mucous membrane of the mouth. A similar aspect of the skin may also be observed in animals which are either partly or altogether covered with white hair. Jaundice is then merely a symptom of disease and ought to direct attention to ascertaining, if possible, the cause or causes which have given rise to it. A swollen condition of the mucous membrane of that part of the bowel called the duodenum may produce jaundice, as that mechanically closes the orifice of the biliary duct. In constipation there is an inactive or torpid condition of the bowel, and the bile which passes into the intestine may be absorbed and cause the yellow staining of jaundice. Jaundice is one of the symptoms of Texas fever. It may also arise from the presence of parasites or gallstones in the ducts, forming a mechanical obstruction to the onward flow of bile. The conditions under which jaundice most commonly calls for treatment are when cattle have been highly fed and kept in a state of inactivity. At such time there is an excess of nutritive elements carried into the blood, which is associated with increased fullness of the portal vein and hepatic artery. When continued high feeding has produced this congested state of the liver, the functions of that organ become disordered, so that a considerable portion of the bile, instead of being excreted and passing into the intestine, is absorbed by the hepatic veins.

The structure of the liver is shown in Plate IV.

_Symptoms._--This disease, although rare, occurs most frequently among stall-fed cattle. Pressure along the margin of the short ribs on the right side produces pain; the appetite is poor and the animal shows hardly any inclination to drink; the mucous membranes of the eye and mouth are yellow, the urine has a yellow or brown appearance, the animal lies down much and moves with reluctance, moans occasionally, and has a tottering gait. The ears and horns are alternately hot and cold; in cows the secretion of milk is much diminished, and that which is secreted has a bitter taste; sometimes the animal has a dry, painful cough and presents a dull, stupefied appearance.

_Treatment._--In such cases it is advisable to produce a free action of the bowels, so as to remove the usually congested condition of the portal vein and liver. For this purpose the administration of the following dose is recommended: Sulphate of soda, 16 ounces; molasses, 1 pint; warm water, 1 quart. The sulphate of soda is dissolved by stirring it up in tepid water. Following this the animal should have a heaping tablespoonful of artificial Carlsbad salt in the feed three times daily. This treatment may be assisted by giving occasional injections of warm water and soap. The diet should be laxative and moderate in quantity and may consist of coarse bran mash, pulped roots, grass in the season, and hay in moderate quantity.

HEPATITIS (INFLAMMATION OF THE LIVER).

Hepatitis is an inflammation of the liver and usually occurs as a complication of some infectious disease. It may also occur as a complication of gastrointestinal catarrh or in hot weather from overheating or damaged (putrid or fermented) feeds.

_Symptoms._--The symptoms are sometimes obscure and their real significance is frequently overlooked. The most prominent symptoms are yellowness of the white of the eye and of the membrane lining the mouth; the appetite is poor, the body presents an emaciated appearance, the feces are light colored, while the urine is likely to be unusually dark; there is thirst, and pain is caused by pressing over the liver. The gait is weak and the animal lies down more than usual, and while doing so frequently rests its head on the side of its chest.

_Treatment._--Give a purge of Glauber's salt and after it has operated give artificial Carlsbad salts in each feed, as advised under "Jaundice." Give green feed and plenty of water. Oil of turpentine should be rubbed in well once a day over the region of the liver. The skin on which it should be applied extends from the false ribs on the right side to 6 inches in front of the last one, and from the backbone to 12 inches on the right side of it.

FLUKE DISEASE.

[See chapter on "The animal parasites of cattle," p. 502.]

SPLENITIS (INFLAMMATION OF THE SPLEEN).

This disease occurs almost solely as a result of the existence of some infectious disease, and the symptoms caused by it merge with the symptoms of the accompanying causative disease. The spleen is seriously involved and becomes enlarged and soft in Texas fever, anthrax, and blood poisoning.

DISEASES OF THE PERITONEUM.

PERITONITIS.

Peritonitis consists of an inflammation of the peritoneum, which is the thin, delicate membrane that lines the abdomen and covers the abdominal organs.

_Causes._--Wounds are the usual cause in cattle. The wound may be of the abdominal wall or of the intestines, stomach, or uterus; or inflammation may extend from one of the organs of the abdominal cavity to the peritoneum; so this disease may complicate enteritis or inflamed womb. A sharp metal body may perforate the second stomach and allow the gastric contents to escape, irritating the peritoneum. This disease may follow castration or operation for hernia.

_Symptoms._--A continuous or occasional shivering; the animal lies down, but appears uneasy; it frequently turns its head toward its belly and lows plaintively; pressure on the flanks produces pain; has no appetite; muzzle is dry and no rumination; while standing, its legs are placed well under its body; pulse small and hard. The evacuations from the bowels are dry and hard. If this disease is complicated by the presence of inflammation of the bowels, the pain is more severe and the animal is more restless. The skin is cold and dry in the early stage of this disease, but in a more advanced stage this condition may be succeeded by heat of the skin and quick breathing. The fits of trembling, uneasiness, small and hard pulse, and tension of the left flank are symptoms the presence of which would enable one to reach the conclusion that peritonitis exists.

_Post-mortem appearance._--The membrane lining the abdomen and covering the surface of the bowels is reddened to a greater or less extent, and there is usually considerable serous, or watery, fluid collected in the abdomen.

_Treatment._--When we have to do with the form of peritonitis resulting from an injury, as when the horn of another animal has been thrust through the abdominal walls, this lesion must be treated in accordance with directions before given, but the general treatment must be similar to that which follows. Peritonitis resulting from castration or from parturient fever must also be treated in connection with the special conditions which give rise to it, as the general treatment of this disease must be modified to some extent by the exciting cause.

The aim must be to discover and remove the cause. The cause must be treated according to its nature. Harms strongly recommends borax in the treatment of peritonitis. He gives 6 ounces in the first 24 hours, divided into three doses, and afterwards he gives 6 drams three times daily. Opium in doses of 2 to 3 drams may be given. To bring on evacuations of the bowels it is better to give rectal injections than to administer purges. The strength may be sustained by coffee or camphor.

The body should be warmly clothed, and it is advisable, when practicable, to have a blanket which has been wrung out of hot water placed over the abdomen, then covered by several dry blankets, which are maintained in position by straps or ropes passing round the body. The wet blanket must be changed as it cools--the object of treatment being to warm the surface of the body and to determine as much blood to the skin as possible. The diet should consist of laxative food and drinks, such as linseed tea. If peritonitis assumes chronic form the diet should be nutritious, such as selected clover hay, linseed cake, grass, etc., and iodid of potassium should be given three times a day in gram doses dissolved in a pint of water.

DROPSY OF THE ABDOMEN (ASCITES).

In this disease there is a serous, or watery, effusion in the cavity of the abdomen.

_Causes._--When old animals are fed on innutritious feed or when reduced by disease, they become anemic; in other words, their blood becomes impoverished and dropsy may follow. An innutritious and insufficient diet produces the same effect in young animals. It is one of the results of peritonitis, and may also arise from acute or chronic inflammation of the liver, such as is of common occurrence when flukes are present in the liver in large numbers. Heart disease and chronic lung disease may be followed by ascites. It is sometimes, in calves, a symptom of infestation with worms.

_Symptoms._--A gradual increase in the size of the abdomen at its lower part, while the flanks becomes hollow; pallor of the mucous membrane of the mouth and eye; weak and sluggish gait; want of appetite, and irregularity in ruminating. On percussion or tapping the surface of the abdomen with the fingers, a dull sound is produced. If the hand and arm are oiled and passed into the rectum as far as possible, on moving the hand from one side to the other the fluctuation caused by the presence of fluid in the abdomen may be felt.

_Treatment._--If possible the cause must be discovered and removed. The diet should be nutritious, and in those cases in which we have merely to deal with anemia (the bloodless state) arising from insufficient diet, the use of tonics and diuretics, at the same time keeping the skin warm, may bring about a gradual absorption of the fluid contained in the abdomen. One of the following powders may be mixed with the animal's feed three times a day; or, if there is any uncertainty as to its being taken in that way, it should be mixed with sirup, so as to form a paste, and smeared well back on the animal's tongue with a flat wooden spoon: Carbonate of iron, 3 ounces; powdered gentian, 3 ounces; powdered nitrate of potassium, 3 ounces; mix and divide into 12 powders. The administration of purgatives which promote a watery discharge from the mucous surface of the bowels also tends, by diminishing the serum of the blood, to bring about absorption and a gradual removal of the fluid contained in the abdomen. Large doses should not be given, but moderate ones should be administered morning and night, so as to produce a laxative effect on the bowels for several days. To attain this end the following may be used: Sulphate of soda, 8 ounces; powdered ginger, half an ounce; to be mixed in 2 quarts of tepid water and given at one dose.

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DISEASES OF THE DIGESTIVE ORGANS.

DESCRIPTION OF PLATES.

PLATE I. Position of the first stomach (rumen or paunch) on the left side. The area inclosed by heavy dotted lines represents the rumen; the elongated, shaded organ is the spleen resting upon it. The skin and muscles have been removed from the ribs to show the position of the lungs and their relation to the paunch.

PLATE II. Stomach of ruminants.

Fig. 1. Stomach of a full-grown sheep, 1/5 natural size (after Thanhoffer, from R. Meade Smith's Physiology of Domestic Animals): _a_, rumen, or first stomach; _b_, reticulum, or second stomach; _c_, omasum, or third stomach; _d_, abomasum, or fourth stomach; _e_, esophagus, or gullet, opening into the first and second stomachs; _f_, opening of fourth stomach into small intestine; _g_, opening of second stomach into third; _h_, opening of third stomach into fourth.

The lines indicate the course of the food in the stomachs. The incompletely masticated food passes down the esophagus, or gullet, into the first and second stomachs, in which a churning motion is kept up, carrying the food from side to side and from stomach to stomach. From the first stomach regurgitation takes place; that is, the food is returned through the gullet to the mouth to be more thoroughly chewed, and this constitutes what is known as "chewing the cud." From the second stomach the food passes into the third, and from the third into the fourth, or true, stomach, and from there into the intestines.

Fig. 2. Stomach of ox (after Colin, from R. Meade Smith's Physiology of Domestic Animals): _a_, rumen; _b_, reticulum; _c_, omasum; _d_, abomasum; _e_, esophagus; _f_, opening of fourth stomach into small intestine.

F¸rstenberg calculated that in an ox of 1,400 pounds weight the capacity of the stomach is as follows:

Per cent. Rumen, 149.25 quarts, liquid measure 62.4 Reticulum, 23.77 quarts 10 Omasum, 36.98 quarts 15 Abomasum, 29.05 quarts 12.6

According to Colon-- Quarts.

The capacity of a beef's stomach is 266.81 Small intestine 69.74 Cecum 9.51 Colon and rectum 25.58

Fig. 1. Clinical thermometer, 4/5 natural size. This is used to determine the temperature of the animal body. The thermometer is passed into the rectum after having been moistened with a little saliva from the mouth, or after having had a little oil or lard rubbed upon it to facilitate its passage. There it is allowed to remain two or three minutes, then withdrawn, and the temperature read as in any ordinary thermometer. The clinical thermometer is made self-registering; that is, the mercury in the stem remains at the height to which it was forced by the heat of the body until it is shaken back into the bulb by taking hold of the upper portion of the instrument and giving it a short, sharp swing. The normal temperature of cattle varies from 100∞ to 103∞ F. In young animals it is somewhat higher than in old. The thermometer is a very useful instrument and frequently is the means by which disease is detected before the appearance of any external sign.

Fig. 2. Simple probang, used to dislodge foreign bodies, like apples, potatoes, eggs, etc., which have become fastened or stuck in the esophagus or gullet.

Fig. 3. Grasping or forceps probang. This instrument, also intended to remove obstructions from the gullet, has a spring forceps at one end in the place of the cup-like arrangement at the end of the simple probang. The forceps are closed while the probang is being introduced; their blades are regulated by a screw in the handle of the instrument. This probang is used to grasp and withdraw an article which may have lodged in the gullet and can not be forced into the stomach by use of the simple probang.

Fig. 4. Wooden gag, used when the probang is to be passed. The gag is a piece of wood which fits in the animal's mouth; a cord passes over the head to hold it in place. The central opening in the wood is intended for the passage of the probang.

Figs. 5_a_ and 5_b._ Trocar and cannula; 5_a_ shows the trocar covered by the cannula; 5_b_, the cannula from which the trocar has been withdrawn. This instrument is used when the rumen or first stomach becomes distended with gas. The trocar covered by the cannula is forced into the rumen, the trocar withdrawn, and the cannula allowed to remain until the gas has escaped.

Fig. 6. Section at right angles through the abdominal wall, showing a hernia or rupture. (Taken from D'Arboval. Dictionnaire de MÈdecine, de Chirurgie de Hygiene): _a a_, The abdominal muscles cut across; _v_, opening in the abdominal wall permitting the intestines _i i_ to pass through and outward between the abdominal wall and the skin; _p p_, peritoneum, or membrane lining the abdominal cavity, carried through the opening _o_ by the loop of intestine and forming the sac S, the outer walls of which are marked _b f b._

PLATE IV. Microscopic anatomy of the liver. The liver is composed of innumerable small lobules, from 1/20 to 1/10 inch in diameter. The lobules are held together by a small amount of fibrous tissue, in which the bile ducts and larger blood vessels are lodged.

Fig. 1 Illustrates the structure of a lobule; _v v_, interlobular veins or the veins between the lobules. These are branches of the portal vein, which carries blood from the stomach and intestines to the liver; _c c_, capillaries, or very fine blood vessels, extending as a very fine network between the groups of liver cells from the interlobular vein to the center of the lobule and emptying there into the intralobular vein to the center of the lobule; _v c_, intralobular vein, or the vein within the lobule. This vessel passes out of the lobule and there becomes the sublobular vein; _v s_, sublobular vein. This joins other similar veins and helps to form the hepatic vein, through which the blood leaves the liver; _d d_, the position of the liver cells between the meshes of the capillaries; _A A_, branches of the hepatic artery to the interlobular connective tissue and the walls of the large veins and large bile ducts. These branches are seen at _r r_ and form the vena vascularis; _v v_, vena vascularis; _i i_, branches of the hepatic artery entering the substance of the lobule and connecting with capillaries from the interlobular vein. The use of the hepatic artery is to nourish the liver, while the other vessels carry blood to be modified by the liver cells in certain important directions; _g_, branches of the bile ducts, carrying bile from the various lobules into the gall bladder and into the intestines; _x x_, intralobular bile capillaries between the liver cells. These form a network of very minute tubes surrounding each ultimate cell, which receives the bile as it is formed by the liver cells and carried outward as described.

Fig. 2. Isolated liver cells: _c_, blood capillary; _a_, fine bile capillary channel.

PLATE V. Ergot in hay: 1, bluegrass; 2, timothy; 3, wild rye; 4, redtop. Ergot is a fungus which may affect any member of the grass family. The spore of the fungus, by some means brought in contact with the undeveloped seed of the grass, grows, obliterates the seed, and practically takes its place. When hay affected with ergot is fed to animals it is productive of a characteristic and serious affection or poisoning known as ergotism.

PLATE VI. Ergotism, or the effects of ergot. The lower part of the limb of a cow, showing the loss of skin and flesh in a narrow ring around the pastern bone and the exposure of the bone itself.

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POISONS AND POISONING.

By V. T. ATKINSON, V. S.

[Revised by C. DWIGHT MARSH, Ph. D.]

DEFINITION OF A POISON.

To define clearly the meaning of the word "poison" is somewhat difficult. Even in law the word has never been defined, and when a definition is attempted we are apt to include either too much or too little. The following definition given by Husemann is perhaps the best: "Poisons are those substances, inorganic or organic, existing in the organism or introduced from the outside, produced artificially or formed as natural products, which, through their chemical nature, under definite conditions, so affect some organ of a living organism that the health or well-being of the organism is temporarily or chronically injured." The common conception of a poison is any substance which, in small quantity, will destroy life, except such as act by purely mechanical means, as, for example, powdered glass.

Some substances that are not usually looked upon as poisons may destroy life if given in large doses, such as common salt. Other substances which are perfectly harmless when taken into the body in the usual way are poisons if injected into the circulation, such as distilled water, milk, or glycerin. Living organisms are not "chemical substances," and are not considered in this connection.

SOURCES OF POISONING.

Poisoning may come from many causes, among the chief of which are the following:

(1) _Errors in medication._--By using the wrong substance or too large dose an animal may be poisoned.

(2) _The exposure of poisons used for horticultural, technical, or other legitimate purposes._--Poisons used for spraying plants, disinfecting, poisoning vermin, dipping cattle or sheep, painting, smelting, dyeing, or other purposes may be so handled as to come within the reach of animals.

(3) _Damaged food._--Food that has undergone putrefaction or certain kinds of fermentation or heating, may have become poisonous, producing forage poisoning, meat poisoning, cheese poisoning, etc.

(4) _Poisonous plants in the pasture or forage._

(5) _The bite or sting of a poisonous insect or the bite of an animal._

(6) _Malicious poisoning._

THE ACTION OF POISONS.

The action of poisons may be either local, and exerted directly on the tissues with which they come in contact, or remote, acting through the circulation or the nervous system; or both local and remote action may be exerted by the same drug. Poisons which act locally generally either destroy by corrosion the tissues with which they come in contact or by inhalation set up acute inflammation. When any corrosive agent is taken into the stomach in poisonous quantities, a group of symptoms is developed which is common to all. The tissues with which the agent comes in contact are destroyed, sloughing and acute inflammation of the surrounding structures take place; intense pain in the abdomen and death ensue. In a like manner, but with less rapidity, the same result is reached if the agent used be not of a sufficiently corrosive nature to destroy the tissues, but sufficiently irritating to set up acute inflammation of the mucous membrane of the digestive tract. If the poison exerts a remote influence alone, the action is quite different, little or no local effect being produced upon the digestive organs.

To produce an effect on some part of the body distant from the channel of entrance, a poison must have been absorbed and carried in the blood to the central nervous system or other region involved. The poisonous effect of any substance is modified by the quantity used; by its chemical combinations; by the part of the animal structure with which it comes in contact; by the physical condition of the subject; and also by the rapidity with which the poison is excreted. As an illustration, opium may be given with safety in much larger doses to an animal suffering from acute pain than to one free from pain, and to an adult animal with greater safety than to a young one. The rapidity with which the poison is absorbed, owing to the part of the body with which it is brought in contact, is also an important factor. So marked is this quality that some agents which have the power of destroying life with almost absolute certainty when introduced beneath the skin, may be taken into the stomach without causing inconvenience, as curara, the arrow poisons, or the venomous secretion of snakes. Other agents in chemical combination may tend to intensify, lessen, or wholly neutralize the poisonous effect. For example, arsenic in itself has well-marked poisonous properties, but when brought in contact with dialyzed iron it forms an insoluble compound and becomes innocuous. Idiosyncrasies are not so noticeable in cattle practice as in practice among human beings, but the uncertainty with which some drugs exert their influence would lead us to believe that well-marked differences in susceptibility exist. Even in some cases a tolerance for poison is engendered, so that in a herd of animals equally exposed injurious or fatal effects do not appear with uniformity. For example, among cattle that are compelled to drink water holding in solution a salt of lead the effects of the poisoning will be found varying all the way from fatality to imperceptibility.

GENERAL SYMPTOMS OF POISONING.

It is not always easy to differentiate between poisoning and some disease. Indeed, examination during the life of the animal is sometimes wholly inadequate to the formation of an opinion as to whether the case is one of poisoning or, if it is, as to what the poison may be. A chemical and physical examination after the death of the animal may be necessary to clear up the doubt. On the other hand, the symptoms may be of such a nature as to point unmistakably to poisoning with a certain agent. In general, the following classes of symptoms may be regarded as indicative of poisoning: Sudden onset of the disease without visible cause, a number of animals being similarly affected at once, with severe gastrointestinal disorder or derangement of the nervous system, or both; sudden alteration of heart action in relation to frequency, force, or rhythm; local irritation, dyspnea, or change in the urine or urination.

After death, lesions of the greatest variety may be found, and it is necessary for one to be skilled in anatomy and pathology in order to determine their significance. Oftentimes the stomach and intestines are red, have thick walls, and contain blood. This signifies a severe irritant, such as arsenic or corrosive sublimate. Other alterations sometimes found are inflammation of the kidneys or bladder, points of hemorrhage in various organs, changes in the blood, congestion of the lungs, and certain microscopic changes.

GENERAL TREATMENT.

The treatment of animals suffering from poison must vary according to the nature of the toxic agent. There are a few general plans of action, however, which should be followed so far as possible. In man and in some of the smaller animals it is possible to eliminate unabsorbed poison by the use of the stomach pump or by causing vomiting. These proceedings are impracticable in cattle. It is well, therefore, in many cases to endeavor to expel the unabsorbed poison by emptying the digestive tract, so far as may be, with a nonirritating purge. Castor oil in doses of 1 pint to 2 quarts is adapted to this purpose. If the poison is known to be nonirritant--as a narcotic plant--from 10 to 20 drops of croton oil may be given with a quart of castor oil. When poisons are somewhat prolonged in their effect, Epsom salt in doses of 1 pound can be given advantageously. To protect the mucous membrane from the action of strong irritants, one may give flaxseed tea, barley water, the whites of eggs, milk, butter, olive oil, or fresh lard. Chemical antidotes may sometimes be used for special poisons, as advised below. In general, if an acid has been taken it may be neutralized with an alkali, such as chalk, magnesia, bicarbonate of soda (baking soda), ammonia (diluted), or soap. If the poison is an alkali, such as caustic soda or potash (lye), or ammonia, an acid, such as diluted (1 per cent) sulphuric acid or vinegar, may be administered. Special treatments and antidotes are considered below.

A poisonous agent may be so gradually introduced into the system as to slowly develop the power of resistance against its own action. In other cases where the poison is introduced slowly the poisonous action becomes accumulative, and, although there is no increase in the quantity taken, violent symptoms are suddenly developed, as if the whole amount, the consumption of which may have extended over a considerable period, had been given in one dose. Other agents, poisonous in their nature, tend to deteriorate some of the important organs, and, interfering with their natural functions, are productive of conditions of ill health which, although not necessarily fatal, are important. Such might properly be called chronic poisons. Poisons of themselves dangerous when administered in large doses are used medicinally for curative purposes, and a very large percentage of the pharmaceutical preparations used in the practice of medicine if given in excessive quantities may produce serious results. In the administration of medicines, therefore, care should be exercised not only that the animal is not poisoned by the administration of an excessive dose but that injury is not done by continued treatment with medicines the administration of which is not called for.

MINERAL POISONS.

ARSENIC POISONING.

Of the common irritant and corrosive poisons, arsenic, especially one of its compounds (Paris green), is likely to be the most dangerous to our class of patients. The common practice of using Paris green and other compounds of arsenic as insecticides for the destruction of potato beetle and other insect enemies of the farmer and fruit grower has had the effect of introducing it into almost all farming establishments. White arsenic is also a principal ingredient in some popular dipping preparations, and poisoning from this source occasionally takes place when, after dipping, animals are allowed to run in a yard in which there is loose fodder. The drippings from the animals falling on the fodder render it poisonous and dangerous to animal life if eaten. Familiarity with its use has in many instances tended to breed contempt for its potency as a poison. Rat poisons often contain arsenic. The excessive use of arsenic as a tonic, or of "condition powders" containing arsenic, has been the means of poisoning many animals. This is the common poison used by malicious persons with criminal intent. The poison may also be absorbed through wounds or through the skin if used as a dip or bath.

If a large dose is given, at once acute poisoning is produced; if repeated small doses are given, chronic poisoning may result. The poisonous dose for an ox is from 3 drams to 1 ounce.

_Symptoms._--The symptoms of acute poisoning first appear as those of colic; the animal is restless, stamping with the feet, lying down and getting up. There is tenderness on pressure over the abdomen. The acute symptoms increase; in a few hours violent diarrhea is developed; in many cases blood and shreds of detached mucous membrane are mixed with the evacuations. There is irregular and feeble pulse and respiration, and death is likely to supervene between the eighteenth hour and the third day. If the latter period is passed, there is a reasonable hope of recovery.

In chronic poisoning the symptoms are similar to those of chronic gastrointestinal catarrh, with indigestion, diarrhea, and general weakness and loss of condition.

_Treatment._--The antidote for arsenic is a solution of hydrated oxid of iron in water. It should be prepared fresh by mixing a solution of sulphate of iron, made by dissolving 4 ounces of sulphate of iron in one-half pint water, with a suspension of 1 ounce of magnesia in one-half pint water. This quantity is sufficient for one dose for a cow and may be repeated in an hour, if much arsenic was taken. A solution of calcined magnesia or powdered iron or iron filings or iron scale from a blacksmith's forge may be given in the absence of other remedies. Powdered sulphur is of some value as an antidote. One must also administer protectives, such as linseed tea, barley water, whites of eggs, etc.

LEAD POISONING.

Lead poisoning of cattle sometimes comes from their having licked freshly painted surfaces and thus swallowed compounds containing white lead. In several instances cattle have been poisoned by silage from a silo painted inside with lead paint shortly before filling. Sometimes cattle eat dried paint scrapings with apparent relish and are poisoned. Cattle grazing on rifle ranges have been poisoned by lead from the bullets. Sugar of lead has been administered by mistake for Glauber's salt. Lead poisoning may be acute or chronic. The fatal dose of sugar of lead is from 1 to 4 ounces. Water drawn from lead pipes or held in a lead-lined tank may cause poisoning.

_Symptoms._--The symptoms are generally dullness, lying down with the head turned toward the flank, colic, rumbling in the abdomen, loss of control of the limbs when walking, twitching, champing of the jaws, moving in a circle, convulsions, delirium, violent bellowing, followed by stupor and death. The symptoms generally extend over considerable time but may end in death after 24 hours.

_Chronic lead poisoning_ occasionally occurs in districts where lead mining is the principal industry. The waste products of the mine thrown into streams contaminate the water supply, so that the mineral is taken into the system gradually, and a very small per cent of any of the salts taken into the system in this way is pernicious. Water which contains any salt of lead to the extent of more than one-tenth of a grain to the gallon is unfit to drink. Such water when used continually is likely to produce colic from the resulting intestinal irritation, and in aggravated cases paralysis more or less severe is likely to be developed. A blue line on the margin of the gums, the last symptom, is regarded as diagnostic and its presence as conclusive evidence of the nature of the disorder.

_Treatment._--The treatment should first be directed toward removing the cause. A large dose of purgative medicine should be given, and the brain symptoms be relieved by giving bromid of potassium in half-ounce doses every 4 or 5 hours and by the application of cold water to the head. Dilute sulphuric acid in half-ounce doses should be given with the purgative medicine. In this case sulphate of magnesia (Epsom salt) is the best purgative, and it may be given in doses of from 1 to 2 pounds dissolved in warm water. After the acute symptoms have abated, iodid of potassium may be given, in doses of 2 drams each, three times a day for a week.

No treatment is likely to be of avail until the cause is removed.

COPPER POISONING.

The soluble salts of copper, though used as a tonic in the medicinal treatment of cattle, are poisonous when taken in large quantities. Like lead and arsenic, they have an irritant effect upon the mucous membrane with which they come in contact in a concentrated form. Cattle are not very likely to be poisoned from this cause unless through carelessness. Sulphate of copper, commonly called blue vitriol, is occasionally used for disinfecting and cleansing stables, where it might inadvertently be mixed with the feed. It is also used largely for making the Bordeaux mixture used in spraying fruit trees. The general symptoms produced are those of intestinal irritation, short breathing, stamping, and tender abdomen.

_Treatment._--Give powdered iron, or iron reduced by hydrogen, or calcined magnesia. Sulphur may be used. This should be followed by a liberal supply of demulcents, linseed infusion, boiled starch, whites of eggs, etc.

ZINC POISONING.

Several of the soluble salts of zinc are irritant poisons. The chlorid and sulphate are those in most common use. In animals which have power to vomit they are emetic in their action. In others, when retained in the stomach, they set up more or less irritation of the mucous membrane and abdominal pain, producing symptoms already described in the action of other poisons which produce the same result.

_Treatment._--The treatment should be the same as for copper poisoning.

PHOSPHORUS POISONING.

Only one of the forms of phosphorus in common use--the ordinary yellow--is poisonous. Phosphorus in this form is used for the destruction of rats and mice and other vermin, and has been largely used in the manufacture of matches.

_Symptoms._--The symptoms are loss of appetite, colic, diarrhea, irritation of the mouth and throat, and paralysis of the throat. There is also weakness, difficult breathing, and rapid pulse. The course of the poisoning is usually rapid, terminating in either recovery or death within three days. The toxic dose for cattle is from 5 to 30 grains. If taken in large quantities the excreta are occasionally noticed to be luminous when examined in the dark.

_Treatment._--Turpentine is given in an emulsion with flaxseed tea in a single dose of from 2 to 8 ounces. Permanganate of potassium may be given in a one-fourth of 1 per cent solution. Stimulants, such as alcohol and ether, should be administered. Oils and milk must not be given.

MERCURY POISONING.

Mercury poisoning is not rare in cattle from the fact that these animals have a special susceptibility to the action of this substance. Antiseptic washes or injections containing the bichlorid of mercury (corrosive sublimate) must be used on cattle with great care. Mercurial disinfecting solutions or salves must be used cautiously. Calomel can not be given freely to cattle.

_Symptoms._--The symptoms are salivation, sore mouth, indigestion, diarrhea, skin eruption, paralysis of local groups of muscles, and nephritis.

_Treatment._--The treatment consists in administering sulphur in large doses (2 to 4 ounces) or iron powder. Both make insoluble compounds with mercury. Follow with the whites of eggs mixed with water and with linseed tea. If the case does not terminate promptly, give iodid of potash in 1-dram doses twice daily.

POISONING BY ACIDS.

MINERAL ACIDS.--The mineral acids--nitric, sulphuric, hydrochloric, etc.-- when used in a concentrated form destroy the animal tissues with which they come in contact, and in this respect differ from most of the poisons previously described. When taken into the stomach the mucous membrane of the mouth, pharynx, esophagus, and stomach is apt to be more or less completely destroyed. If taken in large quantities death is likely to result so speedily that nothing can be done to relieve the patient, and even if time is allowed and the action of the acid can be arrested it can not be done until considerable and, perhaps, irreparable damage has been done. The mucous membrane with which the acid has come in contact in the esophagus may be destroyed by its corrosive action and carried away, leaving the muscular tissues exposed. The raw surface heals irregularly, the cicatrice contracting causes stricture, and an animal so injured is likely to die of starvation. In the stomach even greater damage is likely to be done. The peristaltic action of the esophagus carries the irritant along quickly, but here it remains quiet in contact with one surface, destroying it. It is likely to perforate the organ and, coming in contact with the abdominal lining or other organs of digestion, soon sets up a condition that is beyond repair. In a less concentrated form, when this is not sufficiently strong to be corrosive, it exerts an irritant effect. In this form it may not do much harm unless taken in considerable quantity. When thus the mucous membrane of the stomach and intestines becomes inflamed pain and diarrhea are likely to result.

_Treatment._--Any of the alkalies may be used as an antidote. Most convenient of these are chalk, baking soda, marble dust, magnesia, lime, soap, or plaster from a wall. Mucilaginous drinks should be given in large quantities.

VEGETABLE ACIDS.--Oxalic acid in particular is corrosive in its action when taken in concentrated solution, losing its corrosive effect and becoming irritant when more dilute. It also exerts a specific effect on the heart, frequently causing death from syncope. Taken in the form either of the crystals or solution it is likely to cause death in a very short time. Failure of heart action and the attendant small pulse, weakness, staggering, and convulsions are the more noticeable symptoms. Acetic acid is irritant to the gastrointestinal tract, and may cause sudden paralysis of the heart.

_Treatment._--The action of the acid should be counteracted by the use of alkalies, as advised above, by limewater or lime or plaster given promptly, by protectives to the digestive tract, and by stimulants.

POISONING BY ALKALIES.

The carbonates of potash and soda and the alkalies themselves in concentrated form cause symptoms of intestinal irritation similar to those produced by mineral acids. Ammonia, caustic soda, and caustic potash (lye) are those to which animals are most exposed. The degree of their caustic irritant effects depends on their degree of concentration. When they reach the stomach the symptoms are nearly as well marked as in the case of the acids. The irritation is even more noticeable, and purgation is likely to be a more prominent symptom. If death is not caused soon, the irritation of the gastrointestinal tract and malnutrition will last for a long time.

_Treatment._--Treatment consists in neutralizing the alkali by an acid, such as dilute sulphuric acid (1 per cent) or strong vinegar. The administration of such an antidote and its action must be carefully watched during administration. In the chemical change which takes place when the acid and alkali are combined, carbonic-acid gas is liberated, which may be to an extent sufficient to cause considerable distention of the abdomen, and even to produce asphyxia from pressure forward on the diaphragm. Should this danger present itself, it may be averted by opening the flank, permitting the gas to escape. (See "Acute tympanites, or Bloating," p. 22.) Flaxseed or slippery-elm decoction must be given to sooth the inflamed mucous surface. Opium may be used to allay pain.

COAL-OIL POISONING.

Coal oil is sometimes administered empirically as a treatment for intestinal parasites. If given in large doses it produces poisonous effects, which are likely to be manifested some time after the administration. It acts as an irritant to the digestive tract, causing dribbling of ropy saliva from the mouth, diarrhea, tenesmus, and loss of appetite, with increased temperature and cold extremities. Visible mucous membranes are injected, pupils of the eyes are contracted, and there is a watery discharge from the eyes and nostrils. Remotely it exerts a depressing influence on the functions of the brain and slight coma, and occasionally convulsions, from which the animal is easily aroused. The kidneys also suffer. The urine is dark colored and has the characteristic odor of coal oil. Death may result from gastroenteritis or convulsions.

_Treatment._--The patient's strength should be fostered by the frequent administration of mild stimulants, of which aromatic spirits of ammonia is perhaps the best. The animal should be encouraged to eat soft feed and given mucilaginous drinks.

Crude coal oil is sometimes applied to the skin to kill parasites. If too much is used, especially in hot weather, great weakness and depression may be caused and in some cases death may result.

CARBOLIC-ACID POISONING.

Although one of the most valuable antiseptic remedies, carbolic acid in a concentrated form, when taken internally or used over a large surface externally, is likely to produce poisonous effects. It causes whitening, shrinking, and numbness of the structures with which it comes in contact, and, besides its irritant effect, exerts a powerful influence on the nervous system. Being readily absorbed, it produces its effect whether swallowed, injected into the rectum, inhaled, or applied to wounds, or even to a large tract of unbroken skin. Used extensively as a dressing, it may produce nausea, dizziness, and smoky or blackish colored urine. The last symptom is nearly always noticeable where the poisonous effect is produced. In more concentrated form, or used in larger quantities, convulsions, followed by fatal coma, are likely to take place. Even in smaller quantities, dullness, trembling, and disinclination for food often continue for several days. In a tolerably concentrated solution it coagulates albumen and acts as an astringent.

_Treatment._--As an antidote internally, a solution of sulphate of soda or sulphate of magnesia (Glauber's or Epsom salt) may be given. The white of egg is also useful. Stimulants may be given if needed. When the poisoning occurs through too extensive applications to wounds or the skin, as in treatment of mange, cold water should be freely applied so as to wash off any of the acid that may still remain unabsorbed. As a surgical dressing a 3 per cent solution is strong enough for ordinary purposes. Water will not hold more than 5 per cent in permanent solution. No preparation stronger than the saturated solution should be used medicinally under any circumstances.

SALTPETER POISONING.

Both nitrate of soda and nitrate of potassium are poisonous to cattle. These substances are used for manure and for preserving meats. They may be administered in a drench by error in place of Glauber's salt, or they may be exposed within reach of cattle and thus be eaten. The toxic dose depends upon the condition of fullness of the stomach. If in solution and given on an empty stomach, as little as 3 ounces of saltpeter (nitrate of potassium) may be fatal to a cow. More of the Chile saltpeter (nitrate of soda) is required to cause serious trouble.

_Symptoms._--Severe gastroenteritis, colic, tympanites, diarrhea, excessive urination, weakness, trembling, convulsions, collapse.

_Treatment._--Same as for poisoning by common salt.

POISONING BY COMMON SALT.

A few pounds (3 to 5) of common salt will produce well-marked signs of poisoning in cattle. So much salt as this will not be taken by cattle except under unusual conditions. If the feed is poor in salt, and if no salt has been given for a long time, an intense "salt hunger" may occur that may lead an animal to eat a poisonous quantity, or an overdose of salt may be given by error as a drench. In order to prevent overeating of salt, it is doubtless better in salting cattle to use rock salt rather than that in more or less finely divided form.

Herring and mackerel brine and pork pickle are also poisonous, and are especially dangerous for hogs. In these substances there are, in addition to salt, certain products extracted from the fish or meat which undergo change and add to the toxicity of the solution. Sometimes saltpeter is present in such brines.

_Symptoms._--The symptoms are great thirst, abdominal pain, diarrhea, poor appetite, redness and dryness of the mouth, increased urination, paralysis of the hind legs, weak pulse, general paralysis, coma, and death in from six to eight hours.

_Treatment._--Allow as much warm water as the animal will drink; give protectives, such as linseed tea, etc. Linseed or olive oil may be given. To keep up the heart action give ether, alcohol, camphor, digitalis, or coffee. To allay pain, give opium.

VEGETABLE POISONS.

Vegetable poisons may be divided into two classes--those that are likely to be administered to the animal as medicine, and such as may be taken in the feed, either in the shape of poisonous plants or as plants or feeds of vegetable origin that have been damaged by fungi or by bacteria which have produced fermentation or putrefaction.

VEGETABLE POISONS USED AS MEDICINE.

OPIUM (MORPHIN, LAUDANUM) POISONING.

Opium and its alkaloid, morphia, are so commonly used in the practice of medicine that the poisonous result of an overdose is not uncommon. The common preparations are gum opium, the inspissated juice of the poppy; powdered opium, made from the gum; tincture of opium, commonly called laudanum; and the alkaloid or active principle, morphia. Laudanum has about one-eighth the strength of the gum or powder. Morphia is present in good opium to the extent of about 10 per cent. In medicine it is a most useful agent in allaying pain. It first produces a stimulating action, which is followed by drowsiness, a disposition to sleep or complete anesthesia, depending on the quantity of the drug used. In poisonous doses a state of exhilaration is well marked at first. This is particularly noticeable in cattle and in horses. The animal becomes much excited, and this stage does not pass into insensibility unless an enormous dose has been given. If the dose is large enough, a second stage sometimes supervenes, in which the symptoms are those of congestion of the brain. The visible membranes have a bluish tint (cyanotic) from interference with the air supply. The breathing is slow, labored, and later stertorous; the pupils of the eyes are very much contracted; the skin dry and warm. Gas accumulates in the stomach, so that tympanites is a prominent symptom. The patient may be aroused by great noise or the infliction of sharp pain, when the breathing becomes more natural. A lapse into the comatose condition takes place when the excitement ceases. Later, there is perfect coma and the patient can no longer be aroused from the insensible condition. The contraction of the pupil becomes more marked, the breathing intermittent and slower, there is perspiration, the pulse more feeble and rapid, till death takes place. Poisoning of cattle with opium or its products rarely goes beyond the stage of excitement, because the quantity of the drug required for the later effects is so great. Seventy-five grains of morphia administered subcutaneously has sufficed merely to excite for 12 hours.

_Treatment._--Give strong coffee, 1 to 4 quarts, aromatic spirits of ammonia or carbonate of ammonia. Atropia is the physiological antidote.

STRYCHNIN POISONING.